Ten fire engines and around 70 firefighters have been tackling a fire at an industrial estate on Willoughby Drive in Dagenham.
A number of vehicles, along with scrap metal, is alight.
Although the fire has now been brought under control, firefighters are expected to remain on scene for some time fully extinguishing the flames.
Station Commander Mel Anderson, who is at the scene, said: "This was a very visible fire and it has been producing a lot of smoke.
"We advise people in the area to continue to keep their windows and doors closed at this time. We also request that drivers avoid Rainham Road South with road closures in place whilst this incident is ongoing.
"Two gas cylinders have been removed from the area and cooled to an ambient temperature as a precaution, as some cylinders can explode when exposed to heat.
The Brigade's Control Officers have received more than 50 calls about this fire.
Ten fire engines and around 70 firefighters are attending a fire at an industrial site on Beamway in #Dagenham.
This is a very visible fire and is producing a lot of smoke. Please keep windows and doors closed if you are in the area.
More to follow. https://t.co/1nne9672IB— London Fire Brigade (@LondonFire) April 6, 2025
The Brigade was called at 1409 and Control Officers mobilised crews from Dagenham, Barking, Wennington, Hornchurch, Romford and surrounding fire stations to the scene.
A 32-metre turntable ladder is also at the scene and is being used as a water tower to help extinguish the fire from above.
The fire was brought under control by 1623.
The cause of the fire is unknown at this time.