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Sky Bet League One strugglers Port Vale will travel to Chelsea in the quarter-finals of the FA Cup.
After their shock win over Sunderland on Sunday, Vale, eight points adrift at the bottom of the table, are the lowest-ranked team left in the competition, making it through to the quarter-finals for the first time since 1954.
Chelsea twice came from behind to avoid another upset with a 4-2 extra-time victory over 10-man Wrexham at a raucous Stok Cae Ras.
Premier League leaders Arsenal, having seen off Mansfield on Saturday, will head to Championship side Southampton, who won 1-0 at Fulham with an injury-time penalty from Ross Stewart.
Manchester City – 3-1 winners at Newcastle – will be at home against Liverpool, who saw off Wolves in the fifth round on Friday night.
Leeds, who comfortably beat Norwich 3-0 on Sunday, will travel to West Ham.
The Irons edged past Brentford in a penalty shootout at the London Stadium on Monday night, the tie having finished 2-2 after extra-time.
The quarter-finals will be played around the weekend of April 4.
FA Cup quarter-final draw in full:
Ties will be played around the weekend of April 4-5.